MAPK14

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

1A9U, 1BL6, 1BL7, 1BMK, 1DI9, 1IAN, 1KV1, 1KV2, 1M7Q, 1OUK, 1OUY, 1OVE, 1OZ1, 1R39, 1R3C, 1W7H, 1W82, 1W83, 1W84, 1WBN, 1WBO, 1WBS, 1WBT, 1WBV, 1WBW, 1WFC, 1YQJ, 1ZYJ, 1ZZ2, 1ZZL, 2BAJ, 2BAK, 2BAL, 2BAQ, 2FSL, 2FSM, 2FSO, 2FST, 2GFS, 2I0H, 2LGC, 2NPQ, 2OKR, 2ONL, 2QD9, 2RG5, 2RG6, 2Y8O, 2YIS, 2YIW, 2YIX, 2ZAZ, 2ZB0, 2ZB1, 3BV2, 3BV3, 3BX5, 3C5U, 3CTQ, 3D7Z, 3D83, 3DS6, 3DT1, 3E92, 3E93, 3FI4, 3FKL, 3FKN, 3FKO, 3FL4, 3FLN, 3FLQ, 3FLS, 3FLW, 3FLY, 3FLZ, 3FMH, 3FMJ, 3FMK, 3FML, 3FMM, 3FMN, 3FSF, 3FSK, 3GC7, 3GCP, 3GCQ, 3GCS, 3GCU, 3GCV, 3GFE, 3GI3, 3HA8, 3HEC, 3HEG, 3HL7, 3HLL, 3HP2, 3HP5, 3HRB, 3HUB, 3HUC, 3HV3, 3HV4, 3HV5, 3HV6, 3HV7, 3HVC, 3IPH, 3ITZ, 3IW5, 3IW6, 3IW7, 3IW8, 3K3I, 3K3J, 3KF7, 3KQ7, 3L8S, 3L8X, 3LFA, 3LFB, 3LFC, 3LFD, 3LFE, 3LFF, 3LHJ, 3MGY, 3MH0, 3MH1, 3MH2, 3MH3, 3MPA, 3MPT, 3MVL, 3MVM, 3MW1, 3NEW, 3NNU, 3NNV, 3NNW, 3NNX, 3NWW, 3O8P, 3O8T, 3O8U, 3OBG, 3OBJ, 3OC1, 3OCG, 3OD6, 3ODY, 3ODZ, 3OEF, 3PG3, 3QUD, 3QUE, 3RIN, 3ROC, 3S3I, 3S4Q, 3U8W, 3UVP, 3UVQ, 3UVR, 3ZS5, 3ZSG, 3ZSH, 3ZSI, 3ZYA, 4A9Y, 4AA0, 4AA4, 4AA5, 4AAC, 4DLI, 4DLJ, 4E5A, 4E5B, 4E6A, 4E6C, 4E8A, 4EH2, 4EH3, 4EH4, 4EH5, 4EH6, 4EH7, 4EH8, 4EH9, 4EHV, 4EWQ, 4F9W, 4F9Y, 4FA2, 4GEO, 4KIN, 4KIP, 4KIQ, 4L8M, 3FC1, 4R3C, 5ETC, 5ETI, 4ZTH

Identifiers

Aliases

MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, mitogen-activated protein kinase 14

External IDs

OMIM: 600289 MGI: 1346865 HomoloGene: 31777 GeneCards: MAPK14

Gene ontology
Molecular function	• kinase activity • protein phosphatase binding • ATP binding • protein kinase activity • MAP kinase activity • protein serine/threonine kinase activity • enzyme binding • NFAT protein binding • transferase activity • protein binding • nucleotide binding • MAP kinase kinase activity • mitogen-activated protein kinase p38 binding
Cellular component	• cytosol • mitochondrion • extracellular exosome • spindle pole • cell • extracellular region • nucleoplasm • nuclear speck • secretory granule lumen • ficolin-1-rich granule lumen • nucleus • cytoplasm
Biological process	• positive regulation of glucose import • movement of cell or subcellular component • positive regulation of muscle cell differentiation • placenta development • regulation of transcription from RNA polymerase II promoter • cellular response to DNA damage stimulus • protein phosphorylation • cell surface receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • positive regulation of reactive oxygen species metabolic process • positive regulation of cardiac muscle cell proliferation • regulation of sequence-specific DNA binding transcription factor activity • fatty acid oxidation • angiogenesis • positive regulation of blood vessel endothelial cell migration • glucose metabolic process • cellular response to ionizing radiation • Ras protein signal transduction • negative regulation of canonical Wnt signaling pathway • apoptotic process • response to muscle stretch • cellular response to virus • regulation of transcription, DNA-templated • positive regulation of erythrocyte differentiation • stress-induced premature senescence • osteoclast differentiation • response to muramyl dipeptide • GO:0006350 transcription, DNA-templated • p38MAPK cascade • positive regulation of protein import into nucleus • 3'-UTR-mediated mRNA stabilization • myoblast differentiation involved in skeletal muscle regeneration • chondrocyte differentiation • phosphorylation • signal transduction in response to DNA damage • chemotaxis • positive regulation of myoblast fusion • positive regulation of interleukin-12 secretion • response to lipopolysaccharide • activation of MAPK activity • positive regulation of cyclase activity • cartilage condensation • lipopolysaccharide-mediated signaling pathway • positive regulation of myotube differentiation • GO:0007242 intracellular signal transduction • regulation of cytokine production involved in inflammatory response • DNA damage checkpoint • positive regulation of gene expression • transmembrane receptor protein serine/threonine kinase signaling pathway • positive regulation of myoblast differentiation • peptidyl-serine phosphorylation • cell morphogenesis • striated muscle cell differentiation • cellular response to vascular endothelial growth factor stimulus • cellular response to lipopolysaccharide • positive regulation of brown fat cell differentiation • skeletal muscle tissue development • positive regulation of transcription from RNA polymerase II promoter • signal transduction • regulation of signal transduction by p53 class mediator • regulation of ossification • neutrophil degranulation • positive regulation of cytokine secretion involved in immune response • positive regulation of macrophage chemotaxis • positive regulation of metallopeptidase activity • cellular response to lipoteichoic acid
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1432


26416

Ensembl


ENSG00000112062


ENSMUSG00000053436

UniProt


Q16539


P47811

RefSeq (mRNA)


NM_001315 NM_139012 NM_139013 NM_139014


NM_001168508 NM_001168513 NM_001168514 NM_011951

RefSeq (protein)


NP_001306 NP_620581 NP_620582 NP_620583

NP_001161980.1 NP_001161985.1 NP_001161986.1 NP_036081.1 NP_001161980
NP_001161985 NP_001161986 NP_036081

Location (UCSC)

Chr 6: 36.03 – 36.11 Mb

Chr 17: 28.69 – 28.75 Mb

PubMed search

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