MAPK8

MAPK8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4AWI, 4E73, 4G1W, 4HYS, 4HYU, 4IZY, 4L7F, 4QTD, 4UX9, 4YR8
Identifiers
Aliases	MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
External IDs	MGI: 1346861 HomoloGene: 56760 GeneCards: MAPK8
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • MAP kinase activity • histone deacetylase binding • histone deacetylase regulator activity • protein serine/threonine kinase activity • protein binding • enzyme binding • ATP binding • JUN kinase activity • kinase activity Cellular component • cytosol • nucleoplasm • nucleus • mitochondrion • cytoplasm • neuron projection Biological process • phosphorylation • rhythmic process • response to stress • negative regulation of apoptotic process • negative regulation of protein binding • positive regulation of protein metabolic process • regulation of protein localization • Fc-epsilon receptor signaling pathway • protein phosphorylation • JNK cascade • cellular response to mechanical stimulus • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • positive regulation of gene expression • JUN phosphorylation • regulation of sequence-specific DNA binding transcription factor activity • peptidyl-serine phosphorylation • regulation of circadian rhythm • positive regulation of deacetylase activity • peptidyl-threonine phosphorylation • positive regulation of cyclase activity • cellular response to lipopolysaccharide • response to UV • regulation of macroautophagy • regulation of histone deacetylation • positive regulation of apoptotic process • neuron development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5599	26419
Ensembl	ENSG00000107643	ENSMUSG00000021936
UniProt	P45983	Q91Y86
RefSeq (mRNA)	NM_001278547 NM_001278548 NM_002750 NM_139046 NM_139049 NM_001323302 NM_001323320 NM_001323321 NM_001323322 NM_001323323 NM_001323324 NM_001323325 NM_001323326 NM_001323327 NM_001323328 NM_001323329 NM_001323330 NM_001323331	NM_001310452 NM_001310453 NM_001310454 NM_016700
RefSeq (protein)	NP_001265476 NP_001265477 NP_001310231 NP_001310249 NP_001310250 NP_001310251 NP_001310252 NP_001310253 NP_001310254 NP_001310255 NP_001310256 NP_001310257 NP_001310258 NP_001310259 NP_001310260 NP_620634 NP_620637	NP_057909.1 NP_001297381 NP_001297382 NP_001297383 NP_057909
Location (UCSC)	Chr 10: 48.31 – 48.44 Mb	Chr 14: 33.38 – 33.45 Mb
PubMed search

1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4AWI, 4E73, 4G1W, 4HYS, 4HYU, 4IZY, 4L7F, 4QTD, 4UX9, 4YR8

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