DUSP1

DUSP1
Identifiers
Aliases	DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity phosphatase 1
External IDs	MGI: 105120 HomoloGene: 3254 GeneCards: DUSP1
Gene ontology Molecular function • protein tyrosine/serine/threonine phosphatase activity • protein tyrosine/threonine phosphatase activity • phosphatase activity • protein tyrosine phosphatase activity • protein binding • phosphoprotein phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • growth factor binding • hydrolase activity Cellular component • nucleus • cytoplasm Biological process • positive regulation of apoptotic process • response to estradiol • response to retinoic acid • response to oxidative stress • negative regulation of meiotic cell cycle • response to calcium ion • response to hydrogen peroxide • inactivation of MAPK activity • mitotic cell cycle arrest • response to testosterone • protein dephosphorylation • intracellular signal transduction • negative regulation of MAP kinase activity • negative regulation of MAPK cascade • peptidyl-threonine dephosphorylation • cell cycle • response to light stimulus • negative regulation of DNA biosynthetic process • negative regulation of ERK1 and ERK2 cascade • cellular response to hormone stimulus • dephosphorylation • regulation of apoptotic process • response to glucocorticoid • endoderm formation • peptidyl-tyrosine dephosphorylation • response to organic substance • regulation of mitotic cell cycle spindle assembly checkpoint • negative regulation of apoptotic process • response to cAMP Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1843	19252
Ensembl	ENSG00000120129	ENSMUSG00000024190
UniProt	P28562	P28563
RefSeq (mRNA)	NM_004417	NM_013642
RefSeq (protein)	NP_004408	NP_038670.1 NP_038670
Location (UCSC)	Chr 5: 172.77 – 172.77 Mb	Chr 17: 26.51 – 26.51 Mb
PubMed search

1843

19252

ENSG00000120129

ENSMUSG00000024190

P28562

P28563

NM_004417

NM_013642

NP_004408

NP_038670.1
NP_038670

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

DUSP1 has been shown to interact with MAPK14,MAPK1 and MAPK8.

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Wikipedia