MAPK1

MAPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I
Identifiers
Aliases	MAPK1, ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, mitogen-activated protein kinase 1
External IDs	MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1
Genetically Related Diseases
multiple sclerosis
Gene ontology Molecular function • phosphatase binding • ATP binding • protein kinase activity • transcription factor binding • transferase activity • mitogen-activated protein kinase kinase kinase binding • phosphotyrosine binding • protein binding • protein kinase binding • DNA binding • nucleotide binding • RNA polymerase II carboxy-terminal domain kinase activity • protein serine/threonine kinase activity • kinase activity • identical protein binding • MAP kinase activity Cellular component • cytoplasm • cytosol • focal adhesion • microtubule organizing center • mitochondrion • caveola • dendrite cytoplasm • cytoskeleton • nucleus • extracellular exosome • perikaryon • late endosome • Golgi apparatus • spindle • protein complex • axon • early endosome • mitotic spindle • pseudopodium • extracellular region • nucleoplasm • azurophil granule lumen • ficolin-1-rich granule lumen Biological process • caveolin-mediated endocytosis • positive regulation of telomere capping • response to exogenous dsRNA • cardiac neural crest cell development involved in heart development • positive regulation of translation • cellular response to DNA damage stimulus • platelet activation • Fc-epsilon receptor signaling pathway • protein phosphorylation • face development • cellular response to granulocyte macrophage colony-stimulating factor stimulus • regulation of sequence-specific DNA binding transcription factor activity • animal organ morphogenesis • cell cycle • ERBB signaling pathway • apoptotic process • B cell receptor signaling pathway • MAPK import into nucleus • regulation of transcription, DNA-templated • regulation of protein stability • Fc-gamma receptor signaling pathway involved in phagocytosis • thymus development • negative regulation of cell differentiation • ERK1 and ERK2 cascade • labyrinthine layer blood vessel development • transcription, DNA-templated • positive regulation of transcription, DNA-templated • heart development • viral process • response to toxic substance • regulation of stress-activated MAPK cascade • chemical synaptic transmission • JAK-STAT cascade involved in growth hormone signaling pathway • cytosine metabolic process • phosphorylation • outer ear morphogenesis • response to estrogen • chemotaxis • response to lipopolysaccharide • thyroid gland development • response to epidermal growth factor • activation of MAPK activity • positive regulation of telomerase activity • sensory perception of pain • peptidyl-threonine phosphorylation • trachea formation • lipopolysaccharide-mediated signaling pathway • mammary gland epithelial cell proliferation • intracellular signal transduction • lung morphogenesis • neural crest cell development • positive regulation of cell migration • regulation of early endosome to late endosome transport • response to stress • positive regulation of telomere maintenance via telomerase • MAPK cascade • axon guidance • fibroblast growth factor receptor signaling pathway • positive regulation of peptidyl-threonine phosphorylation • peptidyl-serine phosphorylation • positive regulation of cell proliferation • regulation of cellular response to heat • Bergmann glial cell differentiation • regulation of Golgi inheritance • T cell receptor signaling pathway • regulation of cytoskeleton organization • signal transduction • long-term synaptic potentiation • regulation of ossification • regulation of phosphatidylinositol 3-kinase signaling • neutrophil degranulation • regulation of gene expression • cellular response to organic substance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5594	26413
Ensembl	ENSG00000100030	ENSMUSG00000063358
UniProt	P28482	P63085
RefSeq (mRNA)	NM_138957 NM_002745	NM_001038663 NM_011949
RefSeq (protein)	NP_002736 NP_620407	NP_001033752.1 NP_036079.1 NP_001033752 NP_036079
Location (UCSC)	Chr 22: 21.75 – 21.87 Mb	Chr 16: 16.98 – 17.05 Mb
PubMed search

1PME, 1TVO, 1WZY, 2OJG, 2OJI, 2OJJ, 2Y9Q, 3D42, 3D44, 3I5Z, 3I60, 3SA0, 3TEI, 3W55, 4FMQ, 4FUX, 4FUY, 4FV0, 4FV1, 4FV2, 4FV3, 4FV4, 4FV5, 4FV6, 4FV7, 4FV8, 4FV9, 4G6N, 4G6O, 4H3P, 4H3Q, 4IZ5, 4IZ7, 4IZA, 4N0S, 4NIF, 4O6E, 4QTA, 4QTE, 4ZZM, 4ZZN, 4ZZO, 5BUE, 5BUI, 5BUJ, 4QP1, 4QP2, 4QP3, 4QP4, 4QP6, 4QP7, 4QP8, 4QP9, 4QPA, 4XJ0, 5BVD, 5BVE, 5BVF, 5AX3, 4ZXT, 5K4I

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