Common gamma chain

IL2RG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B5I, 2ERJ, 3BPL, 3QAZ, 3QB7, 4GS7
Identifiers
Aliases	IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
External IDs	OMIM: 308380 MGI: 96551 HomoloGene: 172 GeneCards: IL2RG
Gene ontology Molecular function • interleukin-7 receptor activity • interleukin-2 receptor activity • protein binding • cytokine receptor activity • interleukin-4 receptor activity • Ras guanyl-nucleotide exchange factor activity • interleukin-2 binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane • intracellular Biological process • MAPK cascade • immune response • viral process • signal transduction • interleukin-2-mediated signaling pathway • interleukin-4-mediated signaling pathway • positive regulation of GTPase activity • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3561	16186
Ensembl	ENSG00000147168	ENSMUSG00000031304
UniProt	P31785	P34902
RefSeq (mRNA)	NM_000206	NM_013563 NM_001308535
RefSeq (protein)	NP_000197	NP_001295464 NP_038591
Location (UCSC)	Chr X: 71.11 – 71.11 Mb	Chr X: 101.26 – 101.27 Mb
PubMed search

2B5I, 2ERJ, 3BPL, 3QAZ, 3QB7, 4GS7

3561

16186

ENSG00000147168

ENSMUSG00000031304

P31785

P34902

NM_000206

NM_013563
NM_001308535

NP_000197

NP_001295464
NP_038591

The common gamma chain (γ_c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4,IL-7,IL-9, IL-15 and interleukin-21 receptor. The γ_cglycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals.

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Wikipedia