Interleukin-21 receptor
| IL21R | |||||||||||||||||
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| Aliases | IL21R, CD360, NILR, interleukin 21 receptor | ||||||||||||||||
| External IDs | MGI: 1890475 HomoloGene: 11040 GeneCards: IL21R | ||||||||||||||||
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| Location (UCSC) | Chr 16: 27.4 – 27.45 Mb | Chr 7: 125.6 – 125.63 Mb | |||||||||||||||
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Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
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