Interleukin 21

IL21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OQP, 3TGX
Identifiers
Aliases	IL21, CVID11, IL-21, Za11, interleukin 21
External IDs	OMIM: 605384 MGI: 1890474 HomoloGene: 11032 GeneCards: IL21
Gene ontology Molecular function • cytokine activity • interleukin-2 receptor binding • cytokine receptor binding Cellular component • extracellular region • intracellular • extracellular space Biological process • positive regulation of inflammatory response • positive regulation of cytokine production • cell maturation • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of B cell proliferation • positive regulation of tissue remodeling • positive regulation of T cell proliferation • immune response • positive regulation of cell proliferation • tyrosine phosphorylation of Stat3 protein • positive regulation of interleukin-17 production • positive regulation of natural killer cell mediated cytotoxicity • positive regulation of tyrosine phosphorylation of Stat1 protein • signal transduction • positive regulation of interferon-gamma biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59067	60505
Ensembl	ENSG00000138684	ENSMUSG00000027718
UniProt	Q9HBE4	Q9ES17
RefSeq (mRNA)	NM_021803 NM_001207006	NM_021782 NM_001291041
RefSeq (protein)	NP_001193935 NP_068575	NP_068554.1 NP_001277970 NP_068554
Location (UCSC)	Chr 4: 122.61 – 122.62 Mb	Chr 3: 37.22 – 37.23 Mb
PubMed search

2OQP, 3TGX

59067

60505

ENSG00000138684

ENSMUSG00000027718

Q9HBE4

Q9ES17

NM_021803
NM_001207006

NM_021782
NM_001291041

NP_001193935
NP_068575

NP_068554.1
NP_001277970
NP_068554

Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene.

Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells.

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