Interleukin-9 receptor

IL9R
Identifiers
Aliases	IL9R, CD129, IL-9R, interleukin 9 receptor
External IDs	MGI: 96564 HomoloGene: 37591 GeneCards: IL9R
Gene location (Human) Chr. X chromosome (human) Band No data available Start 155,997,581 bp End 156,010,817 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 32,187,541 bp End 32,200,279 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine receptor activity • interleukin-9 binding • interleukin-9 receptor activity • protein binding Cellular component • integral component of membrane • integral component of plasma membrane • membrane • extracellular region • extracellular space • plasma membrane Biological process • cell proliferation • signal transduction • positive regulation of protein targeting to mitochondrion • cytokine-mediated signaling pathway • interleukin-9-mediated signaling pathway • positive regulation of cell growth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3581	16199
Ensembl	ENSG00000124334	ENSMUSG00000020279
UniProt	Q01113	Q01114
RefSeq (mRNA)	NM_002186 NM_176786	NM_001134458 NM_008374
RefSeq (protein)	NP_002177 NP_789743	NP_001127930 NP_032400
Location (UCSC)	Chr X: 156 – 156.01 Mb	Chr X: 32.19 – 32.2 Mb
PubMed search

3581

16199

ENSG00000124334

ENSMUSG00000020279

Q01113

Q01114

NM_002186
NM_176786

NM_001134458
NM_008374

NP_002177
NP_789743

NP_001127930
NP_032400

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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