Cayuga Creek

Cayuga Creek
Country	United States
State	New York
Region	Western New York
Source
- location	Wyoming County
- coordinates	42°42′48″N 78°21′53″W / 42.71333°N 78.36472°W / 42.71333; -78.36472
Mouth	Buffalo River
- location	Erie County
- coordinates	42°52′12″N 78°47′10″W / 42.87000°N 78.78611°W / 42.87000; -78.78611Coordinates: 42°52′12″N 78°47′10″W / 42.87000°N 78.78611°W / 42.87000; -78.78611
Discharge	for Lancaster, New York
- average	139 cu ft/s (4 m3/s)
Location of the mouth of Cayuga Creek in New York State.

Cayuga Creek is a small stream in western New York, United States, with stretches in both Erie County and Wyoming County. The creek enters Buffalo Creek in the northwest corner of the Town of West Seneca in Erie County, just upstream from the New York State Thruway crossing. At that point, Buffalo Creek becomes the Buffalo River and flows into Lake Erie near Buffalo, New York.

The creek is named after the Cayuga nation, one of the constituent members of the Iroquois Confederacy.

The watershed of Cayuga Creek includes the towns of Alden, Cheektowaga, Elma, Lancaster, and Marilla in Erie County and the towns of Bennington and Sheldon in Wyoming County. Village centers along Cayuga Creek include Lancaster and Depew.

A sewage treatment facility in the Town of Cheektowaga discharges in to Cayuga Creek upstream of Borden Road. Downstream from Borden Road the creek runs along the Indian Road landfill.