CX3CL1

CX3CL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B2T, 1F2L, 3ONA, 4XT1, 4XT3
Identifiers
Aliases	CX3CL1, ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin, C-X3-C motif chemokine ligand 1
External IDs	OMIM: 601880 MGI: 1097153 HomoloGene: 2251 GeneCards: CX3CL1
Gene ontology Molecular function • cytokine activity • chemokine activity • protein binding • CCR chemokine receptor binding • receptor binding • integrin binding • CX3C chemokine receptor binding Cellular component • integral component of membrane • membrane • plasma membrane • extracellular region • cell surface • extracellular space Biological process • G-protein coupled receptor signaling pathway • defense response • positive regulation of inflammatory response • monocyte chemotaxis • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • angiogenesis involved in wound healing • cellular response to tumor necrosis factor • wound healing • leukocyte chemotaxis • neutrophil chemotaxis • positive regulation of angiogenesis • positive regulation of transforming growth factor beta1 production • positive regulation of GTPase activity • cell adhesion • immune response • cellular response to interleukin-1 • leukocyte adhesive activation • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cell chemotaxis • lymphocyte chemotaxis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of calcium-independent cell-cell adhesion • chemotaxis • integrin activation • negative regulation of cell migration • leukocyte migration involved in inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6376	20312
Ensembl	ENSG00000006210	ENSMUSG00000031778
UniProt	P78423	O35188
RefSeq (mRNA)	NM_002996 NM_001304392	NM_009142
RefSeq (protein)	NP_001291321 NP_002987	NP_033168.2 NP_033168
Location (UCSC)	Chr 16: 57.37 – 57.39 Mb	Chr 8: 94.77 – 94.78 Mb
PubMed search

1B2T, 1F2L, 3ONA, 4XT1, 4XT3

6376

20312

ENSG00000006210

ENSMUSG00000031778

P78423

O35188

NM_002996
NM_001304392

NM_009142

NP_001291321
NP_002987

NP_033168.2
NP_033168

Fractalkine also known as chemokine (C-X3-C motif) ligand 1 is a protein that in humans is encoded by the CX3CL1 gene.

Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX₃C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). The polypeptide structure of CX3CL1 differs from the typical structure of other chemokines. For example, the spacing of the characteristic N-terminal cysteines differs; there are three amino acids separating the initial pair of cysteines in CX3CL1, with none in CC chemokines and only one intervening amino acid in CXC chemokines. CX3CL1 is produced as a long protein (with 373-amino acid in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.

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Wikipedia