CX3CR1

CX3CR1
Identifiers
Aliases	CX3CR1, CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, C-X3-C motif chemokine receptor 1
External IDs	OMIM: 601470 MGI: 1333815 HomoloGene: 20350 GeneCards: CX3CR1
Gene ontology Molecular function • G-protein coupled receptor activity • C-X3-C chemokine receptor activity • signal transducer activity • protein binding • chemokine receptor activity • C-X3-C chemokine binding • cytokine receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • neuronal cell body membrane • perinuclear region of cytoplasm • neuron projection Biological process • cellular response to transforming growth factor beta stimulus • positive regulation of neuroblast proliferation • G-protein coupled receptor signaling pathway • chemokine-mediated signaling pathway • memory • microglial cell activation • positive regulation of angiogenesis • chemotaxis • cellular defense response • cell adhesion • negative regulation of cell migration • response to wounding • negative regulation of long-term synaptic potentiation • negative regulation of chronic inflammatory response to non-antigenic stimulus • viral process • cellular response to lipopolysaccharide • signal transduction • microglial cell activation involved in immune response • negative regulation of angiogenesis • cytokine-mediated signaling pathway • cerebral cortex cell migration • macrophage chemotaxis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1524	13051
Ensembl	ENSG00000168329	ENSMUSG00000052336
UniProt	P49238	Q9Z0D9
RefSeq (mRNA)	NM_001337 NM_001171171 NM_001171172 NM_001171174	NM_009987
RefSeq (protein)	NP_001164642 NP_001164643 NP_001164645 NP_001328	NP_034117.3 NP_034117
Location (UCSC)	Chr 3: 39.26 – 39.28 Mb	Chr 9: 119.9 – 120.07 Mb
PubMed search

1524

13051

ENSG00000168329

ENSMUSG00000052336

P49238

Q9Z0D9

NM_001337
NM_001171171
NM_001171172
NM_001171174

NM_009987

NP_001164642
NP_001164643
NP_001164645
NP_001328

NP_034117.3
NP_034117

CX3C chemokine receptor 1 (CX3CR1) also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13) is a protein that in humans is encoded by the CX3CR1 gene. As the name suggests, this receptor binds the chemokine CX3CL1 (also called neurotactin or fractalkine).

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Wikipedia