CCL22

CCL22
Identifiers
Aliases	CCL22, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1, C-C motif chemokine ligand 22
External IDs	OMIM: 602957 MGI: 1306779 HomoloGene: 7529 GeneCards: CCL22
Gene ontology Molecular function • cytokine activity • CCR chemokine receptor binding • chemokine activity Cellular component • extracellular region • extracellular space Biological process • G-protein coupled receptor signaling pathway • monocyte chemotaxis • chemokine-mediated signaling pathway • cell-cell signaling • cellular response to tumor necrosis factor • response to virus • neutrophil chemotaxis • chemotaxis • positive regulation of GTPase activity • immune response • cellular response to interleukin-1 • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cell chemotaxis • lymphocyte chemotaxis • signal transduction • inflammatory response • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6367	20299
Ensembl	ENSG00000102962	ENSMUSG00000031779
UniProt	O00626	O88430
RefSeq (mRNA)	NM_002990	NM_009137
RefSeq (protein)	NP_002981	NP_033163
Location (UCSC)	Chr 16: 57.36 – 57.37 Mb	Chr 8: 94.75 – 94.75 Mb
PubMed search

6367

20299

ENSG00000102962

ENSMUSG00000031779

O00626

O88430

NM_002990

NM_009137

NP_002981

NP_033163

C-C motif chemokine 22 is a protein that in humans is encoded by the CCL22 gene.

The protein encoded by this gene is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4. The gene for CCL22 is located in human chromosome 16 in a cluster with other chemokines called CX3CL1 and CCL17.

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