CCL17

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1NR2, 1NR4

Identifiers

Aliases

CCL17, A-152E5.3, ABCD-2, SCYA17, TARC, C-C motif chemokine ligand 17

External IDs

MGI: 1329039 HomoloGene: 2246 GeneCards: CCL17

Gene ontology
Molecular function	• cytokine activity • CCR chemokine receptor binding • receptor binding • CCR4 chemokine receptor binding • chemokine activity
Cellular component	• extracellular region • extracellular space
Biological process	• G-protein coupled receptor signaling pathway • negative regulation of myoblast differentiation • monocyte chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • neutrophil chemotaxis • multicellular organism development • chemotaxis • positive regulation of GTPase activity • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6361


20295

Ensembl


ENSG00000102970


ENSMUSG00000031780

UniProt


Q92583


n/a

RefSeq (mRNA)


NM_002987


NM_011332

RefSeq (protein)


NP_002978


n/a

Location (UCSC)

Chr 16: 57.4 – 57.42 Mb

Chr 8: 94.81 – 94.81 Mb

PubMed search

n/a

n/a

Chemokine (C-C motif) ligand 17 (CCL17) (also known as TARC) is a small cytokine belonging to the CC chemokine family is also known as thymus and activation regulated chemokine (TARC). CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1.

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