COX-1

PTGS1
Identifiers
Aliases	PTGS1, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, prostaglandin-endoperoxide synthase 1
External IDs	MGI: 97797 HomoloGene: 743 GeneCards: PTGS1
Targeted by Drug
aspirin, bromfenac, diclofenac, fenoprofen, flurbiprofen, ibuprofen, ketoprofen, ketorolac, meclofenamic acid, mefenamic acid, meloxicam, naproxen, nimesulide, oxaprozin, acetaminophen, phenylbutazone, piroxicam, suprofen
Gene ontology Molecular function • oxidoreductase activity • prostaglandin-endoperoxide synthase activity • dioxygenase activity • heme binding • metal ion binding • peroxidase activity Cellular component • nucleus • intracellular membrane-bounded organelle • photoreceptor outer segment • organelle membrane • extracellular exosome • membrane • endoplasmic reticulum • cytoplasm • Golgi apparatus • endoplasmic reticulum membrane Biological process • prostaglandin biosynthetic process • fatty acid biosynthetic process • response to oxidative stress • regulation of cell proliferation • prostaglandin metabolic process • regulation of blood pressure • cyclooxygenase pathway • lipid metabolic process • inflammatory response • xenobiotic metabolic process • fatty acid metabolic process • oxidation-reduction process • cellular oxidant detoxification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5742	19224
Ensembl	ENSG00000095303	ENSMUSG00000047250
UniProt	P23219	P22437
RefSeq (mRNA)	NM_000962 NM_001271164 NM_001271165 NM_001271166 NM_001271367 NM_001271368 NM_080591	NM_008969
RefSeq (protein)	NP_000953 NP_001258093 NP_001258094 NP_001258095 NP_001258296 NP_001258297 NP_542158	NP_032995.1 NP_032995
Location (UCSC)	Chr 9: 122.37 – 122.4 Mb	Chr 2: 36.23 – 36.25 Mb
PubMed search

5742

19224

ENSG00000095303

ENSMUSG00000047250

P23219

P22437

NM_001271368
NM_080591

NM_008969

NP_001258297
NP_542158

NP_032995.1
NP_032995

Cyclooxygenase 1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene. In humans it is one of two cyclooxygenases.

Cyclooxygenase (COX) is the central enzyme in the biosynthetic pathway to prostaglandins from arachidonic acid. This protein was purified more than 20 years ago and cloned in 1988.

There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. This gene encodes COX-1, which regulates angiogenesis in endothelial cells. COX-1 is also involved in cell signaling and maintaining tissue homeostasis. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.

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Wikipedia