Ketoprofen
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| AHFS/Drugs.com | Monograph |
| MedlinePlus | a686014 |
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Oral, topical, intravenous (veterinary use) |
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| Pharmacokinetic data | |
| Protein binding | 99% |
| Biological half-life | 2-2.5 hours |
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| ECHA InfoCard | 100.040.676 |
| Chemical and physical data | |
| Formula | C16H14O3 |
| Molar mass | 254.281 g/mol |
| 3D model (Jmol) | |
| Chirality | Racemic mixture |
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Ketoprofen, (RS)-2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin.
As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD.
Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums.
Ketoprofen topical patches are being used for treatment of musculoskeletal pain.
Ketoprofen can also be used for treatment of some pain, especially nerve pain such as sciatica, postherpetic neuralgia and referred pain for radiculopathy, in the form of a cream, ointment, liquid, spray, or gel, which may also contain ketamine and lidocaine, along with other agents which may be useful, such as cyclobenzaprine, amitriptyline, acyclovir, gabapentin, orphenadrine and other drugs used as NSAIDs or adjuvant, atypical or potentiators for pain treatment.
A systematic review indicated "The efficacy of orally administered ketoprofen in relieving moderate-severe pain and improving functional status and general condition was significantly better than that of ibuprofen and/or diclofenac." A Cochrane review investigating ketoprofen as a single-dose by mouth in acute, moderate-to-severe postoperative pain concluded that its efficacy is equivalent to drugs such as ibuprofen and diclofenac. In particular, after dental surgery, doses >25 mg provide at least 50% pain relief to more than 60% of people treated, giving relief for about 5 hours.
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Wikipedia