Ketorolac
 |
|
 |
|
| Clinical data | |
|---|---|
| Trade names | Toradol, Acular and Sprix |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a693001 |
| License data | |
| Pregnancy category |
|
| Routes of administration |
Oral, I.M., I.V. |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | 100% (All routes) |
| Metabolism | Hepatic |
| Biological half-life | 3.5 h to 9.2 h, young adults; 4.7 h to 8.6 h, elderly (mean age 72) |
| Excretion |
Renal: 91.4% (mean) Biliary: 6.1% (mean) |
| Legal status | |
| Legal status | |
| Identifiers | |
|
|
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| PDB ligand | |
| Chemical and physical data | |
| Formula | C15H13NO3 |
| Molar mass | 255.27 g/mol |
| 3D model (Jmol) | |
| Chirality | Racemic mixture |
|
|
|
|
  (what is this?)
|
|
Ketorolac or ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives, used as an analgesic. Ketorolac was developed in 1989 by Syntex Corp. (now Roche Bioscience, which is a wholly owned subsidiary of Roche holding Ltd., the parent company of Roche). It was approved by FDA on 30 November 1989 and introduced as Toradol by Syntex. The ophthalmic (i.e., eye-drop) form was approved by FDA on 9 November 1992 and was introduced as Acular eye drops by Allergan under license from Syntex. An intranasal formulation of ketorolac tromethamine was approved by FDA on 14 May 2010 and introduced as Sprix Nasal Spray by Daiichi Sankyo for short-term management of moderate to moderately severe pain requiring analgesia at the opioid level.
Ketorolac acts by inhibiting the bodily synthesis of prostaglandins. Ketorolac in its oral (tablet or capsule) and intramuscular (injected) preparations is a racemic mixture of both (S)-(−)-ketorolac, the active isomer, and (R)-(+)-ketorolac. An ophthalmic solution of ketorolac is available and is used to treat eye pain and to relieve the itchiness and burning of seasonal allergies. As of 2015 the cost for a typical course of medication in the United States is less than US$25.
...
Wikipedia