Fenoprofen

Fenoprofen

Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a681026
Pregnancy category	US: D (Evidence of risk) C
Routes of administration	Oral
ATC code	M01AE04 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Metabolism	Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide.
Biological half-life	3 hours
Excretion	Renal (~90%)
Identifiers
IUPAC name 2-(3-phenoxyphenyl)propanoic acid
CAS Number	29679-58-1 Y
PubChem CID	3342
IUPHAR/BPS	4820
DrugBank	DB00573 Y
ChemSpider	3225 Y
UNII	RA33EAC7KY
KEGG	D02350 Y
ChEBI	CHEBI:5004 Y
ChEMBL	CHEMBL1297 Y
ECHA InfoCard	100.047.356
Chemical and physical data
Formula	C15H14O3
Molar mass	242.26986 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(O)C(c2cc(Oc1ccccc1)ccc2)C
InChI InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17) Y Key:RDJGLLICXDHJDY-UHFFFAOYSA-N Y

Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen is marketed in the USA as Nalfon.

As of 2015 the cost for a typical month of medication in the United States is 50 to 100 USD.

Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

False elevation in free and total serum T 3 as measured by Amerlex-M kit.