*** Welcome to piglix ***

CD40L

CD40LG
Protein CD40LG PDB 1aly.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
External IDs OMIM: 300386 MGI: 88337 HomoloGene: 56 GeneCards: CD40LG
RNA expression pattern
PBB GE CD40LG 207892 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000074

NM_011616

RefSeq (protein)

NP_000065

NP_035746.2
NP_035746

Location (UCSC) Chr X: 136.65 – 136.66 Mb Chr X: 57.21 – 57.22 Mb
PubMed search

1ALY, 1I9R, 3LKJ, 3QD6

NM_000074

NM_011616

NP_000065

NP_035746.2
NP_035746

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system.


...
Wikipedia

...