CD132

IL2RG

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2B5I, 2ERJ, 3BPL, 3QAZ, 3QB7, 4GS7

Identifiers

IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma

External IDs

Gene ontology
Molecular function	• interleukin-7 receptor activity • interleukin-2 receptor activity • protein binding • cytokine receptor activity • interleukin-4 receptor activity • Ras guanyl-nucleotide exchange factor activity • interleukin-2 binding
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • external side of plasma membrane • intracellular
Biological process	• cytokine-mediated signaling pathway • MAPK cascade • immune response • viral process • signal transduction • interleukin-2-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-4-mediated signaling pathway • positive regulation of GTPase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3561


16186


ENSG00000147168


ENSMUSG00000031304


P31785


P34902

RefSeq (mRNA)


NM_000206


NM_013563 NM_001308535

RefSeq (protein)


NP_000197


NP_038591.1 NP_001295464 NP_038591

Location (UCSC)

PubMed search

The common gamma chain (γ_c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4,IL-7,IL-9, IL-15 and interleukin-21 receptor. The γ_cglycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals.