Beta-3 adrenergic receptor

ADRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CDW
Identifiers
Aliases	ADRB3, BETA3AR, adrenoceptor beta 3
External IDs	MGI: 87939 HomoloGene: 37250 GeneCards: ADRB3
Targeted by Drug
mirabegron, amibegron, carazolol, Isoprenaline, norepinephrine, bupranolol, carvedilol, levobunolol, nadolol, propranolol, sr-59230a free base, tertatolol
Gene ontology Molecular function • beta-adrenergic receptor activity • G-protein coupled receptor activity • epinephrine binding • protein homodimerization activity • beta3-adrenergic receptor activity • norepinephrine binding • beta-3 adrenergic receptor binding • signal transducer activity • adrenergic receptor activity • protein binding Cellular component • integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane • nucleus Biological process • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • eating behavior • carbohydrate metabolic process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • response to antibiotic • negative regulation of multicellular organism growth • cell-cell signaling • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • aging • receptor-mediated endocytosis • generation of precursor metabolites and energy • activation of adenylate cyclase activity • diet induced thermogenesis • vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure • adenylate cyclase-activating adrenergic receptor signaling pathway • heat generation • brown fat cell differentiation • response to cold • energy reserve metabolic process • temperature homeostasis • desensitization of G-protein coupled receptor protein signaling pathway by arrestin • positive regulation of MAPK cascade • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	155	11556
Ensembl	ENSG00000188778	ENSMUSG00000031489
UniProt	P13945	P25962
RefSeq (mRNA)	NM_000025	NM_013462
RefSeq (protein)	NP_000016	NP_038490.2
Location (UCSC)	Chr 8: 37.96 – 37.97 Mb	Chr 8: 27.23 – 27.25 Mb
PubMed search

2CDW

155

11556

ENSG00000188778

ENSMUSG00000031489

P13945

P25962

NM_000025

NM_013462

NP_000016

NP_038490.2

The beta-3 adrenergic receptor (β₃ adrenoreceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it.

Actions of the β₃ receptor include

It is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Some β₃agonists have demonstrated antistress effects in animal studies, suggesting it also has a role in the central nervous system (CNS). β₃ receptors are found in the gallbladder, urinary bladder, and in brown adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis and thermogenesis in brown fat. In the urinary bladder it is thought to cause relaxation of the bladder and prevention of urination.

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Wikipedia