BMX (gene)

BMX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EKX, 2YS2, 3SXR, 3SXS
Identifiers
Aliases	BMX, ETK, PSCTK2, PSCTK3, BMX non-receptor tyrosine kinase
External IDs	MGI: 1101778 HomoloGene: 20411 GeneCards: BMX
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • signal transducer activity • metal ion binding • kinase activity • protein binding • protein tyrosine kinase activity • receptor binding • ATP binding • non-membrane spanning protein tyrosine kinase activity Cellular component • cytoplasm • cytosol • extrinsic component of cytoplasmic side of plasma membrane • ruffle membrane • nucleoplasm • plasma membrane Biological process • intracellular signal transduction • phosphorylation • NK T cell differentiation • transmembrane receptor protein tyrosine kinase signaling pathway • protein phosphorylation • cell adhesion • regulation of cell proliferation • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • mesoderm development • innate immune response • signal transduction • apoptotic process • phosphatidylinositol biosynthetic process • execution phase of apoptosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	660	12169
Ensembl	ENSG00000102010	ENSMUSG00000031377
UniProt	P51813	P97504
RefSeq (mRNA)	NM_001721 NM_203281 NM_001320866	NM_009759
RefSeq (protein)	NP_001307795 NP_001712 NP_975010	NP_033889
Location (UCSC)	Chr X: 15.46 – 15.56 Mb	Chr X: 164.19 – 164.26 Mb
PubMed search

2EKX, 2YS2, 3SXR, 3SXS

660

12169

ENSG00000102010

ENSMUSG00000031377

P51813

P97504

NM_001721
NM_203281
NM_001320866

NM_009759

NP_001307795
NP_001712
NP_975010

NP_033889

Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene.

Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.

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Wikipedia