TEC (gene)

TEC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LUL
Identifiers
Aliases	TEC, PSCTK4, tec protein tyrosine kinase
External IDs	MGI: 98662 HomoloGene: 1302 GeneCards: TEC
Genetically Related Diseases
rheumatoid arthritis
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase activity • protein binding • protein tyrosine kinase activity • receptor binding • phospholipid binding • ATP binding • lipid binding Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeleton • plasma membrane Biological process • B cell receptor signaling pathway • cell differentiation • intracellular signal transduction • adaptive immune response • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • Fc-epsilon receptor signaling pathway • protein phosphorylation • regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • integrin-mediated signaling pathway • peptidyl-tyrosine phosphorylation • regulation of platelet activation • innate immune response • tissue regeneration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7006	21682
Ensembl	ENSG00000135605	ENSMUSG00000029217
UniProt	P42680	P24604
RefSeq (mRNA)	NM_003215	NM_001113460 NM_001113461 NM_001113464 NM_013689
RefSeq (protein)	NP_003206	NP_001106931.1 NP_001106932.1 NP_001106935.1 NP_001106931 NP_001106932 NP_001106935 NP_038717
Location (UCSC)	Chr 4: 48.14 – 48.27 Mb	Chr 5: 72.76 – 72.87 Mb
PubMed search

2LUL

7006

21682

ENSG00000135605

ENSMUSG00000029217

P42680

P24604

NM_003215

NM_001113460
NM_001113461
NM_001113464
NM_013689

NP_003206

NP_001106935
NP_038717

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

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