ITK (gene)

ITK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SM2, 1SNU, 1SNX, 2E6I, 2LMJ, 2YUQ, 3MIY, 3MJ1, 3MJ2, 3QGW, 3QGY, 3T9T, 3V5J, 3V5L, 3V8T, 3V8W, 4HCT, 4HCU, 4HCV, 4KIO, 4L7S, 4M0Y, 4M0Z, 4M12, 4M13, 4M14, 4M15, 4MF0, 4MF1, 4PP9, 4PPA, 4PPB, 4PPC, 4PQN, 4QD6, 4RFM
Identifiers
Aliases	ITK, EMT, LPFS1, LYK, PSCTK2, IL2 inducible T-cell kinase
External IDs	OMIM: 186973 MGI: 96621 HomoloGene: 4051 GeneCards: ITK
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase activity • protein binding • protein tyrosine kinase activity • receptor binding • ATP binding Cellular component • cytoplasm • cytosol • cell-cell junction • extrinsic component of cytoplasmic side of plasma membrane Biological process • intracellular signal transduction • adaptive immune response • phosphorylation • NK T cell differentiation • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • cytokine production • activation of phospholipase C activity • Fc-epsilon receptor signaling pathway • protein phosphorylation • cellular defense response • regulation of cell proliferation • peptidyl-tyrosine autophosphorylation • interferon-gamma production • T cell receptor signaling pathway • T cell activation • signal transduction • interleukin-4 production • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3702	16428
Ensembl	ENSG00000113263	ENSMUSG00000020395
UniProt	Q08881	Q03526
RefSeq (mRNA)	NM_005546	NM_001281965 NM_001281966 NM_001281967 NM_001281968 NM_010583
RefSeq (protein)	NP_005537	NP_001268894 NP_001268895 NP_001268896 NP_001268897 NP_034713
Location (UCSC)	Chr 5: 157.14 – 157.26 Mb	Chr 11: 46.33 – 46.39 Mb
PubMed search

1SM2, 1SNU, 1SNX, 2E6I, 2LMJ, 2YUQ, 3MIY, 3MJ1, 3MJ2, 3QGW, 3QGY, 3T9T, 3V5J, 3V5L, 3V8T, 3V8W, 4HCT, 4HCU, 4HCV, 4KIO, 4L7S, 4M0Y, 4M0Z, 4M12, 4M13, 4M14, 4M15, 4MF0, 4MF1, 4PP9, 4PPA, 4PPB, 4PPC, 4PQN, 4QD6, 4RFM

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