Atripla
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| Combination of | |
|---|---|
| Efavirenz | non-nucleoside reverse transcriptase inhibitor |
| Emtricitabine | nucleoside analog reverse transcriptase inhibitor |
| Tenofovir disoproxil | nucleotide analog reverse transcriptase inhibitor |
| Clinical data | |
| Trade names | Atripla, Viraday, others |
| AHFS/Drugs.com | Professional Drug Facts |
| Pregnancy category |
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| Routes of administration |
by mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| NIAID ChemDB | |
Efavirenz/emtricitabine/tenofovir, sold under the trade name Atripla among others, is a medication used to treat HIV/AIDS. It is a fixed-dose combination of efavirenz, emtricitabine, and tenofovir disoproxil. It can be used by itself or together with other antiretroviral medications. It is taking by mouth once a day.
Common side effects include headache, trouble sleeping, sleepiness, and unsteadiness. Serious side effects may include high blood lactate levels, psychiatric symptoms, and enlargement of the liver. It should not be used in children. If used during the first trimester of pregnancy harm to the baby may occur.
Efavirenz/emtricitabine/tenofovir was approved for medical use in the United States in 2006. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 10.71 to 14.19 USD per month as of 2014. The wholesale cost in the United States is about 2308.20 USD a month as of 2016 while in the United Kingdom it costs the NHS GB£532.87 per month as of 2015.
Combining the three drugs into a single, once-daily pill reduces pill burden and simplifies dosing schedules, and therefore has the potential to increase adherence to antiretroviral therapy.
People who have shown strong hypersensitivity to efavirenz, a constituent of Atripla, should not take Atripla. Drugs that are contraindicated in the intake of Atripla are: voriconazole, ergot derivative drugs, benzodiazepines midazolam and triazolam, calcium channel blocker bepridil, cisapride, pimozide and St. John’s wort (Hypericum perforatum). Breastfeeding is also contraindicated.
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