Anti-thyroglobulin

TG
Identifiers
Aliases	TG, AITD3, TGN, thyroglobulin
External IDs	OMIM: 188450 MGI: 98733 HomoloGene: 2430 GeneCards: TG
Gene location (Human) Chr. Chromosome 8 (human) Band No data available Start 132,866,958 bp End 133,134,903 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band No data available Start 66,670,753 bp End 66,850,721 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • hormone activity Cellular component • extracellular region • extracellular space Biological process • thyroid hormone metabolic process • thyroid gland development • regulation of myelination • iodide transport • signal transduction • hormone biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7038	21819
Ensembl	ENSG00000042832	ENSMUSG00000053469
UniProt	P01266	O08710
RefSeq (mRNA)	NM_003235	NM_009375
RefSeq (protein)	NP_003226	NP_033401
Location (UCSC)	Chr 8: 132.87 – 133.13 Mb	Chr 8: 66.67 – 66.85 Mb
PubMed search

7038

21819

ENSG00000042832

ENSMUSG00000053469

P01266

O08710

NM_003235

NM_009375

NP_003226

NP_033401

Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland. Human TG is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide may be removed from the N-terminus in the mature protein).

The protein is a precursor of the thyroid hormones; these are produced when thyroglobulin's tyrosine residues are combined with iodine and the protein is subsequently cleaved. Each thyroglobulin molecule contains approximately 100-120 tyrosine residues, but only a small number (20) of these are subject to iodination by thyroperoxidase in the follicular colloid. Therefore, each Tg molecule forms only approximately 10 thyroid hormone molecules.

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Wikipedia