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Thyroperoxidase

iodide peroxidase
Identifiers
EC number 1.11.1.8
CAS number 9031-28-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
thyroid peroxidase
Identifiers
Symbol TPO
Entrez 7173
HUGO 12015
OMIM 606765
RefSeq NM_175722
UniProt P07202
Other data
EC number 1.11.1.8
Locus Chr. 2 pter-p24

Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene.

L-Tyrosin + I + H+ + H2O23-Iod-L-Tyrosin + 2 H2O

Iodide is oxidized to iodine radical which immediately reacts with tyrosine.

3-Iod-L-Tyrosin + I + H+ + H2O23,5-Diiod-L-Tyrosin + 2 H2O


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Wikipedia

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