Aldolase B

ALDOB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1QO5, 1XDL, 1XDM
Identifiers
Aliases	ALDOB, Aldob, Aldo-2, Aldo2, BC016435, ALDB, aldolase, fructose-bisphosphate B
External IDs	MGI: 87995 HomoloGene: 20060 GeneCards: ALDOB
Gene location (Human) Chr. Chromosome 9 (human) Band 9q31.1 Start 101,420,578 bp End 101,435,823 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band n/a Start 49,535,995 bp End 49,549,546 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • fructose-1-phosphate aldolase activity • ATPase binding • cytoskeletal protein binding • fructose binding • protein binding • catalytic activity • lyase activity • identical protein binding • fructose-bisphosphate aldolase activity Cellular component • cytoplasm • centriolar satellite • microtubule organizing center • extracellular exosome • cytoskeleton • cytosol Biological process • gluconeogenesis • positive regulation of ATPase activity • glycolytic process • vacuolar proton-transporting V-type ATPase complex assembly • canonical glycolysis • fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate • fructose 1,6-bisphosphate metabolic process • NADH oxidation • fructose metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	229	230163
Ensembl	ENSG00000136872	ENSMUSG00000028307
UniProt	P05062	Q91Y97
RefSeq (mRNA)	NM_000035	NM_144903
RefSeq (protein)	NP_000026	NP_659152
Location (UCSC)	Chr 9: 101.42 – 101.44 Mb	Chr 9: 49.54 – 49.55 Mb
PubMed search

1QO5, 1XDL, 1XDM

229

230163

ENSG00000136872

ENSMUSG00000028307

P05062

Q91Y97

NM_000035

NM_144903

NP_000026

NP_659152

Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 4.1.2.13), and plays a key role in both glycolysis and gluconeogenesis. The generic fructose 1,6-bisphosphate aldolase enzyme catalyzes the reversible cleavage of fructose 1,6-bisphosphate (FBP) into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP) as well as the reversible cleavage of fructose 1-phosphate (F1P) into glyceraldehyde and dihydroxyacetone phosphate. In mammals, aldolase B is preferentially expressed in the liver, while aldolase A is expressed in muscle and erythrocytes and aldolase C is expressed in the brain. Slight differences in isozyme structure result in different activities for the two substrate molecules: FBP and fructose 1-phosphate. Aldolase B exhibits no preference and thus catalyzes both reactions, while aldolases A and C prefer FBP.

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Wikipedia