Aldolase C

ALDOC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XFB
Identifiers
Aliases	ALDOC, ALDC, Aldolase C, aldolase, fructose-bisphosphate C
External IDs	MGI: 101863 HomoloGene: 21073 GeneCards: ALDOC
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 28,573,115 bp End 28,577,264 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 78,322,968 bp End 78,327,781 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytoskeletal protein binding • protein binding • catalytic activity • lyase activity • fructose-bisphosphate aldolase activity Cellular component • cytosol • extracellular exosome • cytoskeleton • mitochondrion • extracellular region • secretory granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen Biological process • gluconeogenesis • fructose metabolic process • glycolytic process • epithelial cell differentiation • canonical glycolysis • fructose 1,6-bisphosphate metabolic process • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	230	11676
Ensembl	ENSG00000109107	ENSMUSG00000017390
UniProt	P09972	P05063
RefSeq (mRNA)	NM_005165	NM_009657 NM_001303423
RefSeq (protein)	NP_005156	NP_001290352 NP_033787
Location (UCSC)	Chr 17: 28.57 – 28.58 Mb	Chr 17: 78.32 – 78.33 Mb
PubMed search

1XFB

230

11676

ENSG00000109107

ENSMUSG00000017390

P09972

P05063

NM_005165

NM_009657
NM_001303423

NP_005156

NP_001290352
NP_033787

Aldolase C, fructose-bisphosphate (ALDOC, or ALDC), is an enzyme that, in humans, is encoded by the ALDOC gene on chromosome 17. This gene encodes a member of the class I fructose-bisphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively.[provided by RefSeq, Jul 2008]

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