ACHE, AChE, acetylhydrolase, acetylcholinesterase (Yt blood group), ACEE, ARN-YT, acetylcholinesterase (Cartwright blood group), true cholinesterase (dated synonym)

External IDs

MGI: 87876 HomoloGene: 543 GeneCards: ACHE

Genetically Related Diseases

type 2 diabetes mellitus

Targeted by Drug

donepezil, galantamine, neostigmine, physostigmine, pralidoxime, pyridostigmine, rivastigmine, tacrine

Gene ontology
Molecular function	• protein homodimerization activity • collagen binding • acetylcholine binding • serine hydrolase activity • carboxylic ester hydrolase activity • beta-amyloid binding • cholinesterase activity • protein self-association • protein binding • laminin binding • hydrolase activity • acetylcholinesterase activity
Cellular component	• Golgi apparatus • membrane • plasma membrane • synapse • basal lamina • extracellular region • cell surface • cell junction • perinuclear region of cytoplasm • anchored component of membrane • nucleus • synaptic cleft • extracellular space • neuromuscular junction
Biological process	• muscle organ development • receptor internalization • neurotransmitter biosynthetic process • negative regulation of synaptic transmission, cholinergic • amyloid precursor protein metabolic process • protein tetramerization • acetylcholine catabolic process • nervous system development • neurotransmitter catabolic process • DNA replication • cell adhesion • retina development in camera-type eye • response to wounding • positive regulation of protein secretion • osteoblast development • synapse assembly • phosphatidylcholine biosynthetic process • regulation of receptor recycling • cell proliferation • acetylcholine catabolic process in synaptic cleft • neurotransmitter receptor biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


43


11423

Ensembl


ENSG00000087085


ENSMUSG00000023328

UniProt


P22303


P21836

RefSeq (mRNA)


NM_000665 NM_001282449 NM_001302621 NM_001302622 NM_015831


NM_001290010 NM_009599

RefSeq (protein)


NP_000656 NP_001269378 NP_001289550 NP_001289551 NP_056646


NP_001276939.1 NP_033729.1 NP_001276939 NP_033729

Location (UCSC)

Chr 7: 100.89 – 100.9 Mb

Chr 5: 137.29 – 137.29 Mb

PubMed search

4EY7, 4PQE, 1F8U, 3LII, 4BDT, 4M0E, 4M0F, 1VZJ, 2X8B, 1B41, 4EY4, 4EY5, 4EY6, 4EY8, 5FOQ, 5HF9, 5HF6, 5FPQ, 5HF8, 5HFA

...
Wikipedia