Acetylcholinesterase

acetylcholinesterase

Acetylcholinesterase catalyzes this hydrolysis of acetylcholine to acetate and choline

Identifiers

Databases

metabolic pathway

PDB structures

RCSB PDB PDBe PDBsum

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ACHE

PBB Protein ACHE image.jpg

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4EY7, 4PQE, 1F8U, 3LII, 4BDT, 4M0E, 4M0F, 1VZJ, 2X8B, 1B41, 4EY4, 4EY5, 4EY6, 4EY8, 5FOQ, 5HF9, 5HF6, 5FPQ, 5HF8, 5HFA

Identifiers

ACHE, AChE, acetylhydrolase, acetylcholinesterase (Yt blood group), ACEE, ARN-YT, acetylcholinesterase (Cartwright blood group)

External IDs

MGI: 87876 HomoloGene: 543 GeneCards: ACHE

Genetically Related Diseases

type 2 diabetes mellitus

Targeted by Drug

donepezil, galantamine, neostigmine, physostigmine, pralidoxime, pyridostigmine, rivastigmine, tacrine

Gene ontology
Molecular function	• protein homodimerization activity • collagen binding • acetylcholine binding • serine hydrolase activity • carboxylic ester hydrolase activity • beta-amyloid binding • cholinesterase activity • protein self-association • protein binding • laminin binding • hydrolase activity • acetylcholinesterase activity
Cellular component	• Golgi apparatus • membrane • plasma membrane • synapse • basal lamina • extracellular region • cell surface • cell junction • perinuclear region of cytoplasm • anchored component of membrane • nucleus • synaptic cleft • extracellular space • neuromuscular junction
Biological process	• muscle organ development • receptor internalization • neurotransmitter biosynthetic process • negative regulation of synaptic transmission, cholinergic • amyloid precursor protein metabolic process • protein tetramerization • acetylcholine catabolic process • nervous system development • neurotransmitter catabolic process • DNA replication • cell adhesion • retina development in camera-type eye • response to wounding • positive regulation of protein secretion • osteoblast development • synapse assembly • phosphatidylcholine biosynthetic process • regulation of receptor recycling • cell proliferation • acetylcholine catabolic process in synaptic cleft • neurotransmitter receptor biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE ACHE 205377 s at tn.png

PBB GE ACHE 205378 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


43


11423


ENSG00000087085


ENSMUSG00000023328


P22303


P21836

RefSeq (mRNA)


NM_000665 NM_001282449 NM_001302621 NM_001302622 NM_015831


NM_001290010 NM_009599

RefSeq (protein)


NP_000656 NP_001269378 NP_001289550 NP_001289551 NP_056646


NP_001276939.1 NP_033729.1 NP_001276939 NP_033729

Location (UCSC)

Chr 7: 100.89 – 100.9 Mb

Chr 5: 137.29 – 137.29 Mb

PubMed search

4EY7, 4PQE, 1F8U, 3LII, 4BDT, 4M0E, 4M0F, 1VZJ, 2X8B, 1B41, 4EY4, 4EY5, 4EY6, 4EY8, 5FOQ, 5HF9, 5HF6, 5FPQ, 5HF8, 5HFA

ENSG00000087085

ENSMUSG00000023328

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