ARHGAP5

ARHGAP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE4, 2EE5
Identifiers
Aliases	ARHGAP5, GFI2, RhoGAP5, p190-B, p190BRhoGAP, Rho GTPase activating protein 5
External IDs	MGI: 1332637 HomoloGene: 907 GeneCards: ARHGAP5
Gene ontology Molecular function • GTP binding • SH2 domain binding • protein binding • GTPase activator activity • GTPase activity Cellular component • endoplasmic reticulum • membrane • cytoplasm • cytosol Biological process • cell adhesion • regulation of small GTPase mediated signal transduction • Rho protein signal transduction • signal transduction • mammary gland development • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	394	11855
Ensembl	ENSG00000100852	ENSMUSG00000035133
UniProt	Q13017	P97393
RefSeq (mRNA)	NM_001030055 NM_001173	NM_009706
RefSeq (protein)	NP_001025226 NP_001164	NP_033836
Location (UCSC)	Chr 14: 32.08 – 32.16 Mb	Chr 12: 52.5 – 52.57 Mb
PubMed search

2EE4, 2EE5

394

11855

ENSG00000100852

ENSMUSG00000035133

Q13017

P97393

NM_001030055
NM_001173

NM_009706

NP_001025226
NP_001164

NP_033836

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.

Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family that may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.

ARHGAP5 has been shown to interact with Rnd1,Rnd2,Rnd3 and RHOA.

...
Wikipedia