Rnd1

RND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CLS, 2REX, 3Q3J
Identifiers
Aliases	RND1, ARHS, RHO6, RHOS, Rnd1, Rho family GTPase 1
External IDs	MGI: 2444878 HomoloGene: 8706 GeneCards: RND1
Gene location (Human) Chr. Chromosome 12 (human) Band n/a Start 48,857,145 bp End 48,865,898 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band n/a Start 98,663,421 bp End 98,677,461 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • receptor binding • protein binding • GTPase activity Cellular component • cytoplasm • adherens junction • cytosol • cytoskeleton • membrane • plasma • actin cytoskeleton • intracellular membrane-bounded organelle • intracellular Biological process • neuron remodeling • small GTPase mediated signal transduction • negative regulation of cell adhesion • actin filament organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27289	223881
Ensembl	ENSG00000172602	ENSMUSG00000054855
UniProt	Q92730	Q8BLR7
RefSeq (mRNA)	NM_014470	NM_172612
RefSeq (protein)	NP_055285	NP_766200
Location (UCSC)	Chr 12: 48.86 – 48.87 Mb	Chr 12: 98.66 – 98.68 Mb
PubMed search

2CLS, 2REX, 3Q3J

27289

223881

ENSG00000172602

ENSMUSG00000054855

Q92730

Q8BLR7

NM_014470

NM_172612

NP_055285

NP_766200

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]

Rnd1 has been shown to interact with GRB7,PLXNB1,PDE6D,ARHGAP5 and UBXD5.

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