Rnd3

RND3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M7B, 2V55, 4BG6
Identifiers
Aliases	RND3, ARHE, Rho8, RhoE, memB, Rnd3, Rho family GTPase 3
External IDs	MGI: 1921444 HomoloGene: 21074 GeneCards: RND3
Gene location (Human) Chr. Chromosome 2 (human) Band n/a Start 150,468,195 bp End 150,539,011 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band n/a Start 51,130,438 bp End 51,149,111 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • protein binding • GTPase activity Cellular component • Golgi membrane • Golgi apparatus • extracellular exosome • membrane • focal adhesion • intracellular Biological process • small GTPase mediated signal transduction • cell adhesion • actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390	74194
Ensembl	ENSG00000115963	ENSMUSG00000017144
UniProt	P61587	P61588
RefSeq (mRNA)	NM_005168 NM_001254738	NM_028810
RefSeq (protein)	NP_001241667 NP_005159	NP_083086
Location (UCSC)	Chr 2: 150.47 – 150.54 Mb	Chr 2: 51.13 – 51.15 Mb
PubMed search

1M7B, 2V55, 4BG6

390

74194

ENSG00000115963

ENSMUSG00000017144

P61587

P61588

NM_005168
NM_001254738

NM_028810

NP_001241667
NP_005159

NP_083086

Rnd3 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND3.

Like other members of the Rho family of Ras-related GTPases it regulates the organization of the actin cytoskeleton in response to extracellular growth factors.

Like Ras, Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998).[supplied by OMIM]

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