ARG2

ARG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PQ3, 4HZE, 4I06, 4IE2, 4IE3, 4IXU, 4IXV
Identifiers
Aliases	ARG2, arginase 2
External IDs	OMIM: 107830 MGI: 1330806 HomoloGene: 906 GeneCards: ARG2
Gene ontology Molecular function • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines • arginase activity • hydrolase activity • metal ion binding Cellular component • mitochondrial matrix • mitochondrion Biological process • urea cycle • ureteric bud development • nitric oxide biosynthetic process • striated muscle contraction • arginine metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	384	11847
Ensembl	ENSG00000081181	ENSMUSG00000021125
UniProt	P78540	O08691
RefSeq (mRNA)	NM_001172	NM_009705
RefSeq (protein)	NP_001163	NP_033835
Location (UCSC)	Chr 14: 67.62 – 67.65 Mb	Chr 12: 79.13 – 79.16 Mb
PubMed search

1PQ3, 4HZE, 4I06, 4IE2, 4IE3, 4IXU, 4IXV

384

11847

ENSG00000081181

ENSMUSG00000021125

P78540

O08691

NM_001172

NM_009705

NP_001163

NP_033835

Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene.

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.

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