5-HT4

HTR4
Identifiers
Aliases	HTR4, 5-HT4, 5-HT4R, 5-HT4 receptor, 5-hydroxytryptamine receptor 4
External IDs	MGI: 109246 HomoloGene: 20243 GeneCards: HTR4
Targeted by Drug
vilazodone, pathogen, 5-methoxytryptamine, α-methyl-5-HT, mosapride, renzapride, zacopride, prucalopride, RS 67333, gr-113808, piboserod, SB 204070
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • trace-amine receptor activity Cellular component • cytoplasm • integral component of membrane • endosome • plasma membrane • integral component of plasma membrane • membrane Biological process • gamma-aminobutyric acid signaling pathway • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • regulation of appetite • signal transduction • chemical synaptic transmission • G-protein coupled serotonin receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3360	15562
Ensembl	ENSG00000164270	ENSMUSG00000026322
UniProt	Q13639	P97288
RefSeq (mRNA)	NM_000870 NM_001040169 NM_001040172 NM_001040173 NM_001040174 NM_001286410 NM_199453	NM_008313
RefSeq (protein)	NP_000861 NP_001035259 NP_001035262 NP_001035263 NP_001273339 NP_955525	NP_032339.2 NP_032339
Location (UCSC)	Chr 5: 148.45 – 148.68 Mb	Chr 18: 62.32 – 62.47 Mb
PubMed search

3360

15562

ENSG00000164270

ENSMUSG00000026322

Q13639

P97288

NM_001286410
NM_199453

NM_008313

NP_955525

NP_032339.2
NP_032339

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.

This gene is a member of the family of human serotonin receptors, which are G protein-coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined.

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