*** Welcome to piglix ***

ΔFosB

FOSB
Identifiers
Aliases FOSB, AP-1, G0S3, GOS3, GOSB, FosB, ΔFosB, FosB proto-oncogene, AP-1 trancription factor subunit, FosB proto-oncogene, AP-1 transcription factor subunit
External IDs MGI: 95575 HomoloGene: 31403 GeneCards: FOSB
RNA expression pattern
PBB GE FOSB 202768 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001114171
NM_006732

NM_008036
NM_001347586

RefSeq (protein)

NP_001107643
NP_006723

NP_032062.1
NP_001334515
NP_032062

Location (UCSC) Chr 19: 45.47 – 45.48 Mb Chr 7: 19.3 – 19.31 Mb
PubMed search

NM_001114171
NM_006732

NM_008036
NM_001347586

NP_001107643
NP_006723

NP_032062.1
NP_001334515
NP_032062

FBJ murine osteosarcoma viral oncogene homolog B, also known as FOSB or FosB, is a protein that, in humans, is encoded by the FOSB gene.

The FOS gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants ΔFosB and (further truncated) Δ2ΔFosB are all involved in osteosclerosis, even though Δ2ΔFosB lacks a known transactivation domain, preventing it from affecting gene transcription through the AP-1 complex.


...
Wikipedia

...