Δ-opioid receptor

OPRD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N6H, 4RWA, 4RWD
Identifiers
Aliases	OPRD1, OPRD, Δ-opioid receptor, opioid receptor delta 1
External IDs	MGI: 97438 HomoloGene: 20252 GeneCards: OPRD1
Targeted by Drug
cebranopadol, hydromorphone, nalbuphine, meperidine, Beta-endorphin, DADLE, dihydromorphine, diprenorphine, endomorphin-1, etonitazene, fentanyl, levomethadone, morphine, (-)-pentazocine, SNC80, nalmefene, nalorphine, alvimopan anhydrous, methylnaltrexone, naloxone, naltrexone, naltriben, naltrindole, quadazocine
Gene ontology Molecular function • enkephalin receptor activity • G-protein coupled receptor activity • neuropeptide binding • signal transducer activity • opioid receptor activity • protein binding Cellular component • cytoplasm • axon terminus • integral component of membrane • vesicle • postsynaptic membrane • membrane • intrinsic component of plasma membrane • plasma membrane • integral component of plasma membrane • dendrite membrane • membrane raft • neuron projection Biological process • G-protein coupled receptor signaling pathway • regulation of calcium ion transport • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • regulation of sensory perception of pain • eating behavior • adult locomotory behavior • negative regulation of protein oligomerization • cellular response to growth factor stimulus • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein import into nucleus, translocation • cellular response to toxic substance • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • regulation of mitochondrial membrane potential • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of CREB transcription factor activity • opioid receptor signaling pathway • immune response • neuropeptide signaling pathway • cellular response to hypoxia • signal transduction • chemical synaptic transmission • sensory perception of pain Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4985	18386
Ensembl	ENSG00000116329	ENSMUSG00000050511
UniProt	P41143	P32300
RefSeq (mRNA)	NM_000911	NM_013622
RefSeq (protein)	NP_000902	NP_038650.3 NP_038650
Location (UCSC)	Chr 1: 28.81 – 28.87 Mb	Chr 4: 132.11 – 132.14 Mb
PubMed search

4N6H, 4RWA, 4RWD

4985

18386

ENSG00000116329

ENSMUSG00000050511

P41143

P32300

NM_000911

NM_013622

NP_000902

NP_038650.3
NP_038650

The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is a 7-transmembrane G-protein coupled receptor, that has enkephalins as its endogenous ligands. The regions of the brain where the δ-opioid receptor is largely expressed vary from species model to species model. In humans, the δ-opioid receptor is most heavily expressed in the basal ganglia and neocortical regions of the brain; the basal ganglia, which is heavily GABA populated, has been linked to major depressive disorder, suggesting a possible role for the δ-opioid receptor in mood modulation.

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Wikipedia