Α1D-adrenergic

ADRA1D
Identifiers
Aliases	ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
External IDs	MGI: 106673 HomoloGene: 551 GeneCards: ADRA1D
Genetically Related Diseases
pre-eclampsia
Targeted by Drug
epinephrine, α-methylnoradrenaline, methoxamine, norepinephrine, oxymetazoline, alfuzosin, bmy-7378 free base, clozapine, cyproheptadine, dapiprazole, doxazosin, indoramin, ketanserin, labetalol, mianserin, NAN 190, risperidone, ritanserin, silodosin, spiperone, spiroxatrine, tamsulosin, terazosin, WB-4101, phentolamine, prazosin
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • adrenergic receptor activity • protein binding • alpha1-adrenergic receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • G-protein coupled receptor signaling pathway • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • DNA metabolic process • multicellular organism development • adenylate cyclase-activating adrenergic receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of vasoconstriction • positive regulation of cell proliferation • cell proliferation • positive regulation of smooth muscle contraction • signal transduction • adrenergic receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	146	11550
Ensembl	ENSG00000171873	ENSMUSG00000027335
UniProt	P25100	P97714
RefSeq (mRNA)	NM_000678	NM_013460
RefSeq (protein)	NP_000669 NP_000669.1	n/a
Location (UCSC)	Chr 20: 4.22 – 4.25 Mb	Chr 2: 131.55 – 131.56 Mb
PubMed search

146

11550

ENSG00000171873

ENSMUSG00000027335

P25100

P97714

NM_000678

NM_013460

NP_000669
NP_000669.1

n/a

The alpha-1D adrenergic receptor (α_1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.

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Wikipedia