Alpha-1B-adrenergic receptor

ADRA1B
Identifiers
Aliases	ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs	MGI: 104774 HomoloGene: 55477 GeneCards: ADRA1B
Targeted by Drug
epinephrine, methoxamine, norepinephrine, oxymetazoline, phenylephrine, alfuzosin, bmy-7378 free base, clozapine, cyproheptadine, doxazosin, indoramin, ketanserin, L-765314, mianserin, NAN 190, phentolamine, risperidone, ritanserin, silodosin, spiroxatrine, terazosin, WB-4101, prazosin, spiperone, tamsulosin
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • adrenergic receptor activity • protein heterodimerization activity • alpha1-adrenergic receptor activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • nucleus • nuclear membrane • plasma membrane Biological process • regulation of muscle contraction • intracellular signal transduction • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • glucose homeostasis • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • cell-cell signaling • multicellular organism development • adenylate cyclase-activating adrenergic receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • regulation of vasoconstriction • positive regulation of vasoconstriction • regulation of cardiac muscle contraction • cell proliferation • positive regulation of smooth muscle contraction • positive regulation of MAPK cascade • signal transduction • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	147	11548
Ensembl	ENSG00000170214	ENSMUSG00000050541
UniProt	P35368	P97717
RefSeq (mRNA)	NM_000679	NM_001284380 NM_001284381 NM_007416
RefSeq (protein)	NP_000670	n/a
Location (UCSC)	Chr 5: 159.92 – 159.97 Mb	Chr 11: 43.77 – 43.9 Mb
PubMed search

147

11548

ENSG00000170214

ENSMUSG00000050541

P35368

P97717

NM_000679

NM_001284380
NM_001284381
NM_007416

NP_000670

n/a

The alpha-1B adrenergic receptor (α_1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Alpha-1B adrenergic receptor has been shown to interact with AP2M1. A role in regulation of dopaminergic neurotransmission has also been suggested.

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Wikipedia