ZFPM2

ZFPM2
Identifiers
Aliases	ZFPM2, DIH3, FOG2, ZC2HC11B, ZNF89B, hFOG-2, SRXY9, zinc finger protein, FOG family member 2
External IDs	MGI: 1334444 HomoloGene: 8008 GeneCards: ZFPM2
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription coactivator activity • transcription corepressor activity • RNA polymerase II transcription factor binding • zinc ion binding • transcription factor binding • metal ion binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • nucleic acid binding Cellular component • cytoplasm • nucleoplasm • nucleus Biological process • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • embryonic organ development • lung development • cardiac muscle tissue development • ventricular septum morphogenesis • right ventricular cardiac muscle tissue morphogenesis • blood coagulation • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • negative regulation of cell death • transcription, DNA-templated • outflow tract septum morphogenesis • vasculogenesis • positive regulation of transcription, DNA-templated • heart development • negative regulation of female gonad development • gonadal mesoderm development • negative regulation of transcription, DNA-templated • positive regulation of male gonad development • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cardiac muscle cell proliferation • cell differentiation • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23414	22762
Ensembl	ENSG00000169946	ENSMUSG00000022306
UniProt	Q8WW38	Q8CCH7
RefSeq (mRNA)	NM_012082	NM_011766
RefSeq (protein)	NP_036214	NP_035896.1 NP_035896
Location (UCSC)	Chr 8: 104.59 – 105.8 Mb	Chr 15: 40.66 – 41.1 Mb
PubMed search

23414

22762

ENSG00000169946

ENSMUSG00000022306

Q8WW38

Q8CCH7

NM_012082

NM_011766

NP_036214

NP_035896.1
NP_035896

Zinc finger protein ZFPM2 is a protein that in humans is encoded by the ZFPM2 gene.

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.

Mutations in ZFPM2 cause Congenital Diaphragmatic Hernia .

ZFPM2 has been shown to interact with GATA4,GATA1 and CTBP2.

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Wikipedia