GATA4

GATA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M9W
Identifiers
Aliases	GATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF
External IDs	MGI: 95664 HomoloGene: 1551 GeneCards: GATA4
Gene ontology Molecular function • NFAT protein binding • DNA binding • sequence-specific DNA binding • co-SMAD binding • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription coactivator activity • zinc ion binding • transcription factor binding • chromatin binding • activating transcription factor binding • metal ion binding • transcription factor activity, RNA polymerase II transcription factor binding • protein binding • enhancer sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein kinase binding Cellular component • nucleoplasm • RNA polymerase II transcription factor complex • nucleus • nuclear body Biological process • endoderm development • male gonad development • regulation of transcription, DNA-templated • ventricular septum development • cell growth involved in cardiac muscle cell development • embryonic foregut morphogenesis • endocardial cushion development • cardiac muscle cell differentiation • cell-cell signaling • response to mechanical stimulus • blood coagulation • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of angiogenesis • positive regulation of transcription, DNA-templated • heart looping • atrial septum morphogenesis • response to vitamin A • regulation of cardiac muscle cell contraction • atrial septum secundum morphogenesis • atrial septum primum morphogenesis • intestinal epithelial cell differentiation • embryonic heart tube anterior/posterior pattern specification • positive regulation of BMP signaling pathway • positive regulation of cardioblast differentiation • positive regulation of vascular endothelial growth factor production • negative regulation of autophagy • cardiac ventricle morphogenesis • cardiac right ventricle morphogenesis • response to drug • cellular response to glucose stimulus • positive regulation of transcription from RNA polymerase II promoter • transdifferentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2626	14463
Ensembl	ENSG00000136574	ENSMUSG00000021944
UniProt	P43694	Q08369
RefSeq (mRNA)	NM_001308093 NM_001308094 NM_002052	NM_008092 NM_001310610
RefSeq (protein)	NP_001295022 NP_001295023 NP_002043	NP_001297539 NP_032118
Location (UCSC)	Chr 8: 11.68 – 11.76 Mb	Chr 14: 63.2 – 63.27 Mb
PubMed search

2M9W

2626

14463

ENSG00000136574

ENSMUSG00000021944

P43694

Q08369

NM_001308093
NM_001308094
NM_002052

NM_008092
NM_001310610

NP_001295022
NP_001295023
NP_002043

NP_001297539
NP_032118

Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.

This gene encodes a member of the GATA family of zinc finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects as well as reproductive defects.

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