YWHAG

YWHAG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B05, 3UZD, 4E2E, 4J6S, 4O46, 5D3E
Identifiers
Aliases	YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
External IDs	MGI: 108109 HomoloGene: 22725 GeneCards: YWHAG
Genetically Related Diseases
multiple sclerosis
Gene ontology Molecular function • insulin-like growth factor receptor binding • protein domain specific binding • receptor tyrosine kinase binding • protein binding • protein kinase C binding • protein kinase C inhibitor activity • RNA binding Cellular component • cytoplasm • cytosol • membrane • focal adhesion • myelin sheath • extracellular exosome • cytoplasmic vesicle membrane • mitochondrion • vesicle Biological process • regulation of neuron differentiation • protein targeting • negative regulation of protein kinase activity • regulation of synaptic plasticity • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of signal transduction • G2/M transition of mitotic cell cycle • cellular response to insulin stimulus • membrane organization • negative regulation of protein serine/threonine kinase activity • ciliary basal body docking Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7532	22628
Ensembl	ENSG00000170027	ENSMUSG00000051391
UniProt	P61981	P61982
RefSeq (mRNA)	NM_012479	NM_018871
RefSeq (protein)	NP_036611	NP_061359.2 NP_061359
Location (UCSC)	Chr 7: 76.33 – 76.36 Mb	Chr 5: 135.91 – 135.93 Mb
PubMed search

2B05, 3UZD, 4E2E, 4J6S, 4O46, 5D3E

7532

22628

ENSG00000170027

ENSMUSG00000051391

P61981

P61982

NM_012479

NM_018871

NP_036611

NP_061359.2
NP_061359

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene.

This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.

...
Wikipedia