RAF1

RAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA, 4IHL
Identifiers
Aliases	RAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf
External IDs	OMIM: 164760 MGI: 97847 HomoloGene: 48145 GeneCards: RAF1
Genetically Related Diseases
hypertrophic cardiomyopathy
Targeted by Drug
sorafenib, vemurafenib
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • signal transducer activity, downstream of receptor • metal ion binding • protein serine/threonine kinase activity • small GTPase binding • protein binding • identical protein binding • protein heterodimerization activity • ATP binding • kinase activity • MAP kinase kinase kinase activity • enzyme binding • mitogen-activated protein kinase kinase binding Cellular component • cytoplasm • cytosol • Golgi apparatus • pseudopodium • membrane • plasma membrane • mitochondrial outer membrane • mitochondrion • nucleus • nuclear speck • intracellular Biological process • response to muscle stretch • regulation of apoptotic process • cell differentiation • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein phosphorylation • intracellular signal transduction • response to hypoxia • somatic stem cell population maintenance • phosphorylation • thymus development • cellular glucose homeostasis • negative regulation of protein complex assembly • wound healing • stimulatory C-type lectin receptor signaling pathway • negative regulation of apoptotic process • activation of adenylate cyclase activity • MAPK cascade • positive regulation of peptidyl-serine phosphorylation • regulation of cell motility • platelet activation • protein phosphorylation • heart development • thyroid gland development • ion transmembrane transport • face development • death-inducing signaling complex assembly • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • intermediate filament cytoskeleton organization • regulation of cell differentiation • cell proliferation • regulation of Rho protein signal transduction • signal transduction • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • insulin secretion involved in cellular response to glucose stimulus • apoptotic process • neurotrophin TRK receptor signaling pathway • activation of MAPKK activity • multicellular organism development • negative regulation of signal transduction • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5894	110157
Ensembl	ENSG00000132155	ENSMUSG00000000441
UniProt	P04049	Q99N57
RefSeq (mRNA)	NM_002880	NM_029780
RefSeq (protein)	NP_002871	NP_084056.1 NP_084056
Location (UCSC)	Chr 3: 12.58 – 12.66 Mb	Chr 6: 115.62 – 115.68 Mb
PubMed search

1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA, 4IHL

5894

110157

ENSG00000132155

ENSMUSG00000000441

P04049

...
Wikipedia