William Prusoff
| William Herman Prusoff | |
|---|---|
William Prusoff (Photo: Laura Prusoff)
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| Born |
June 25, 1920 Brooklyn, New York |
| Died | April 3, 2011 (aged 90) New Haven, Connecticut |
| Nationality | American |
| Fields | Pharmacology, AIDS, virus, antiviral, herpes simplex virus, keratitis, HIV, protease inhibitor, virology |
| Institutions |
Case Western Reserve William H. Prusoff Foundation Yale University |
| Alma mater |
University of Miami Columbia University |
| Spouse | Brigitte Prusoff (née Auerbach) (1926-1991) (2 children) |
William Herman Prusoff (June 25, 1920 – April 3, 2011) was a pharmacologist who was an early innovator in antiviral drugs, developing idoxuridine, the first antiviral agent approved by the FDA, in the 1950s, and co-developing (with Tai-shun Lin) stavudine, one of the earliest AIDS drugs, in the mid-1980s.
William Prusoff attended the University of Miami. After receiving his undergraduate degree in chemistry, he obtained his PhD from Columbia University and later completed his postdoctoral training in the laboratory of professor Arnold Welch at Case Western Reserve University. After dr. Welch was recruited by Yale to head the Medical School's pharmacology department, Bill was invited to join the same department as an assistant professor and was subsequently promoted to the rank of professor. This relationship at Yale would span over the next 58 years, with William Prusoff becoming one of Yale's most well respected scientists and teachers.
Prusoff spent most of his career studying analogs of thymidine, a nucleoside building block of DNA, with an eye toward developing therapeutic agents. By exploring analogs to thymidine for use as antiviral drugs, his research created a new scientific paradigm for antiviral drug development.
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