The West Coast Main Line (WCML) is the most important intercity rail passenger route in the United Kingdom, connecting the major cities of London, Birmingham, Coventry, Edinburgh, Glasgow, Liverpool and Manchester. which have a combined metropolitan population of over 24 million people. In addition, several sections of the WCML form part of the suburban railway systems in London, Birmingham, Manchester and Glasgow, with many more smaller commuter stations, as well as providing links to more rural towns. In 2008 the WCML handled 75 million passenger journeys.
It is one of the busiest freight routes in Europe, carrying 43% of all UK rail freight traffic. The line is the principal rail freight corridor linking the European mainland (via the Channel Tunnel) through London and South East England to the West Midlands, North West England and Scotland. The line has been declared a strategic European route and designated a priority Trans-European Networks (TENS) route.
Much of the line has a maximum speed of 125 mph (201 km/h), meeting the European Union's definition of an upgraded high-speed line, although only Class 390 Pendolinos and Class 221 Super Voyagers with tilting mechanisms operated by Virgin Trains travel at that speed. Other traffic is limited to 110 mph (177 km/h).
The core section between London Euston and Glasgow Central is 399-mile (642 km) long with principal InterCity stations at Milton Keynes Central, Rugby, Stafford, Crewe, Warrington Bank Quay, Wigan, Preston, Lancaster, Oxenholme, Penrith and Carlisle. The length of the core section is nominally quoted as 401.25 miles (645.75 km). This is the distance between the midpoint of Platform 18 of London Euston to that of Platform 1 of Glasgow Central, and historically is the distance used in official calculations during speed record attempts.