Vertebrate telomerase RNA

TERC
Identifiers
Aliases	TERC, DKCA1, PFBMFT2, SCARNA19, TR, TRC3, hTR, Telomerase RNA component
External IDs	GeneCards: TERC
Orthologs
Species	Human	Mouse
Entrez	7012	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search		n/a

Vertebrate telomerase RNA
Identifiers
Symbol	Telomerase-vert
Rfam	RF00024
Other data
RNA type	Gene
Domain(s)	Eukaryote; Virus
SO	{{{SO}}}

Ciliate telomerase RNA
Identifiers
Symbol	Telomerase-cil
Rfam	RF00025
Other data
RNA type	Gene
Domain(s)	Eukaryote
SO	{{{SO}}}

Saccharomyces cerevisiae telomerase RNA
Identifiers
Symbol	Sacc_telomerase
Rfam	RF01050
Other data
RNA type	Gene
Domain(s)	Eukaryote
SO	{{{SO}}}

7012

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Telomerase RNA component, also known as TERC, is an ncRNA found in eukaryotes, that is a component of telomerase - The enzyme used to extend telomeres. TERC serves as a template for telomere replication (reverse transcription) by telomerase. Telomerase RNAs differ greatly in sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence. The vertebrate telomerase RNAs have a 3' H/ACA snoRNA-like domain.

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. This repeat does vary across eukaryotes (see the table on the telomere article for a complete list). The enzyme consists of a protein component (TERT) with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. CCCUAA found near position 50 of the vertebrate TERC sequence acts as the template. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.Homologs of TERC can also be found in the Gallid herpes viruses.

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