TERT

TERT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BCK, 4B18, 4MNQ
Identifiers
Aliases	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase
External IDs	OMIM: 187270 MGI: 1202709 HomoloGene: 31141 GeneCards: TERT
Gene location (Human) Chr. Chromosome 5 (human) Band No data available Start 1,253,147 bp End 1,295,069 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band No data available Start 73,626,911 bp End 73,649,843 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • DNA binding • nucleotidyltransferase activity • telomeric DNA binding • tRNA binding • metal ion binding • RNA-directed 5'-3' RNA polymerase activity • telomerase RNA reverse transcriptase activity • protein binding • transcription coactivator binding • telomerase RNA binding • telomerase activity • protein homodimerization activity • chaperone binding • RNA-directed DNA polymerase activity • template-free RNA nucleotidyltransferase • RNA binding • protein C-terminus binding • protein N-terminus binding Cellular component • cytoplasm • PML body • nuclear telomere cap complex • RNA-directed RNA polymerase complex • intracellular ribonucleoprotein complex • nucleoplasm • chromosome • chromosome, telomeric region • telomerase catalytic core complex • nucleolus • mitochondrion • TERT-RMRP complex • mitochondrial nucleoid • nuclear chromosome, telomeric region • nucleus • plasma membrane • telomerase holoenzyme complex Biological process • positive regulation of protein localization to nucleolus • telomere maintenance via telomerase • DNA biosynthetic process • regulation of protein stability • replicative senescence • RNA-dependent DNA biosynthetic process • mitochondrion organization • negative regulation of gene expression • transcription, RNA-templated • positive regulation of Wnt signaling pathway • production of siRNA involved in RNA interference • positive regulation of nitric-oxide synthase activity • establishment of protein localization to telomere • negative regulation of production of siRNA involved in RNA interference • DNA strand elongation • positive regulation of protein binding • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • telomere maintenance • RNA biosynthetic process • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of cellular senescence • response to cadmium ion • positive regulation of G1/S transition of mitotic cell cycle • beta-catenin-TCF complex assembly • negative regulation of apoptotic process • positive regulation of glucose import • positive regulation of angiogenesis • positive regulation of vascular associated smooth muscle cell migration • negative regulation of glial cell proliferation • positive regulation of transdifferentiation • cellular response to hypoxia • positive regulation of vascular smooth muscle cell proliferation • negative regulation of endothelial cell apoptotic process • negative regulation of neuron apoptotic process • positive regulation of hair cycle • positive regulation of stem cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7015	21752
Ensembl	ENSG00000164362	ENSMUSG00000021611
UniProt	O14746	O70372
RefSeq (mRNA)	NM_001193376 NM_198253 NM_198254 NM_198255	NM_009354
RefSeq (protein)	NP_001180305 NP_937983	NP_033380
Location (UCSC)	Chr 5: 1.25 – 1.3 Mb	Chr 5: 73.63 – 73.65 Mb
PubMed search

2BCK, 4B18, 4MNQ

7015

21752

ENSG00000164362

ENSMUSG00000021611

O14746

O70372

NM_001193376
NM_198253
NM_198254
NM_198255

NM_009354

NP_001180305
NP_937983

NP_033380

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

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