VMAT2

SLC18A2

Identifiers

SLC18A2, SVAT, SVMT, VAT2, VMAT2, solute carrier family 18 member A2

External IDs

Gene ontology
Molecular function	• monoamine transmembrane transporter activity • serotonin transmembrane transporter activity
Cellular component	• integral component of membrane • clathrin-sculpted monoamine transport vesicle membrane • membrane • plasma membrane • integral component of plasma membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • synaptic vesicle
Biological process	• locomotory behavior • response to amphetamine • post-embryonic development • serotonin transport • negative regulation of reactive oxygen species biosynthetic process • dopamine transport • transport • neurotransmitter loading into synaptic vesicle • neurotransmitter transport • response to toxic substance • neurotransmitter secretion • sequestering of neurotransmitter • chemical synaptic transmission • monoamine transport • transmembrane transport • aminergic neurotransmitter loading into synaptic vesicle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6571


214084


ENSG00000165646


ENSMUSG00000025094


Q05940


Q8BRU6

RefSeq (mRNA)


NM_003054


NM_172523

RefSeq (protein)


NP_003045


NP_766111.1 NP_766111

Location (UCSC)

PubMed search

The vesicular monoamine transporter 2 (VMAT2) also known as solute carrier family 18 member 2 (SLC18A2) is a protein that in humans is encoded by the SLC18A2 gene. VMAT2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles. In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, VMAT2 function is also necessary for the vesicular release of the neurotransmitter GABA.