UCK2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1UDW, 1UEI, 1UEJ, 1UFQ, 1UJ2, 1XRJ

Identifiers

Aliases

UCK2, TSA903, UK, UMPK, uridine-cytidine kinase 2

External IDs

MGI: 1931744 HomoloGene: 40850 GeneCards: UCK2

Gene ontology
Molecular function	• transferase activity • nucleotide binding • nucleoside kinase activity • uridine kinase activity • ATP binding • kinase activity
Cellular component	• cytosol
Biological process	• pyrimidine nucleoside salvage • CMP salvage • metabolic process • UMP salvage • CTP salvage • phosphorylation • pyrimidine nucleobase metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7371


80914

Ensembl


ENSG00000143179


ENSMUSG00000026558

UniProt


Q9BZX2


Q99PM9

RefSeq (mRNA)


NM_012474


NM_030724

RefSeq (protein)


NP_036606


NP_109649

Location (UCSC)

Chr 1: 165.83 – 165.91 Mb

Chr 1: 167.22 – 167.29 Mb

PubMed search

1UDW, 1UEI, 1UEJ, 1UFQ, 1UJ2, 1XRJ

Uridine-cytidine kinase 2 is an enzyme that in humans is encoded by the UCK2 gene.

The protein encoded by this gene catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.

Uridine-cytidine kinase 2 is a tetramer with molecular mass of about 112 kDa. In the UCK2 monomer, the active site is composed of a five-stranded β-sheet, surrounded by five α-helices and a β-hairpin loop. The β-hairpin loop in particular forms a significant portion of a deep binding pocket for the uridine/cytidine substrate to moderate binding and release of substrate and products. Binding specificity for nucleosides is determined by the His-117 and Tyr-112 residues, which hydrogen bond with the 4-amino group or the 6-oxo group of cytidine and uridine, respectively. A magnesium ion is coordinated in the active site by Glu-135, Ser-34, and Asp-62.

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