U.S. Route 412
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| Route information | |
| Length: | 1,130 mi (1,819 km) |
| Existed: | 1982 (extended east in 1984, 1989, west in 1989, 1994) – present |
| Major junctions | |
| West end: |
   I-25 Bus. / US 56 / NM 21 at Springer, NM
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 I-40 at Jackson, TN
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| East end: |
  I-65 / SR 99 at Columbia, TN
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| Location | |
| States: | New Mexico, Oklahoma, Arkansas, Missouri, Tennessee |
| Highway system | |
I‑35 near Enid, OK
I‑44 at Tulsa, OK
I-49 / US 62 / US 71 at Springdale, AR
I-55 at Caruthersville, MO
I-155 / US 51 at Dyersburg, TN
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